A Mighty Pen
Chemical Heritage Foundation
Sheldon Kaplan Obituary
Sheldon Kaplan EpiPen
Origin of the EpiPen
From Sheldon Kaplan to Mylan PharmaceuticalsWhile Mylan Pharmaceuticals is cashing in on the EpiPen price hikes, the inventor of the life-saving device, who made it for the public, died in obscurity.
Sheldon Kaplan, who was an engineer for NASA before inventing the EpiPen, lived a humble, middle-class lifestyle. His surviving family members say he was never paid royalties for the device he invented, and never became famous for designing a product now used by millions. The One Disturbing Secret About EpiPen Big Pharma Hopes You Never Find Out
A Ritch Heritage of Inovation
Speed is often of the essence in the midst of a critical situation. Delivering an antidote or medication rapidly in an acute medical crisis can be lifesaving.1 Meridian's long history of working closely with such entities as the United States Army and NASA has allowed us to create innovative drug delivery systems to help meet the needs of those responding to certain medical crises. Merididianmeds
Bovet and his research student Anne-Marie Staub succeeded in synthesizing the first antihistamine. This first attempt was too toxic to use in humans, however, so from 1937
to 1941 Bovet conducted thousands of experiments to produce a usable antihistamine. He succeeded with pyrilamine, which was introduced to the
public in 1944.
NY TImes George Rieveschl, a chemical engineer (not a medical doctor) whom millions of sufferers of allergies, colds, rashes, hives and hay fever can thank for the relief they receive by swallowing a capsule of beta-dimethylaminoethylbenzhydryl ether hydrochloride — the antihistamine he invented and renamed Benadryl
Who invented the Auvi-Q Epinephrine
King Menses of Egipt
"Perhaps the earliest report of allergic disease is that of King Menses of Egypt, who was killed by the sting of a wasp at some time between 3640 and 3300 BC. Another report from ancient history is that of Britannicus, the son of the Roman Emperor Claudius. He was allergic to horses and "would develop a rash and his eyes swelled to the extent that he could not see where he was going". Accordingly, the honour of riding at the head of the young patricians fell to Nero who was Claudius’s adopted son. Nero allegedly threw Christians to the lions and killed Britannicus.
Sir Thomas More gives the next authoritative account of allergy: King Richard III used his allergy to strawberries to good effect in arranging the judicial murder of Lord William Hastings. The King surreptitiously ate some strawberries just prior to giving an audience to Hastings and promptly developed acute urticaria. He then accused Hastings of putting a curse on him, an action that demanded the head of Hastings on a plate."
King Richard III
Did you know that the lowly strawberry is responsible for a major historical event? It's true. Though England's King Richard III (1452-1485) is now famous mostly for his purportedly hunched back, tyrannical rule and subsequent unflattering immortalization by Shakespeare, he may also have been the first to inflict death by dessert. According to a biography written by Sir Thomas More (1478-1535), Richard was mistrustful of his old friend, Lord William Hastings (1431-1483) — a powerful figure who was sympathetic to the throne's rightful heir, the young Edward V (1470-1483) — and needed to do away with him in order to accede the throne. Richard, who was allergic to strawberries, secretly ate a few before meetings with Hastings one day. After falling ill quickly and dramatically, he publicly accused Hastings of putting a curse on him. The hapless Hastings was then arrested on charges of treason and dispatched in the first recorded execution at the Tower of London. Richard was coronated a week later. From Doctors Review
Early Records of Anaphylaxis
"Professor Charles Robert Richet, Nobel Prize Winner for Medicine and Physiology in 1913, for the discovery of anaphylaxis. With his versatile personality he was involved in
many different fields. His investigative work included diverse themes such as respiration, digestion, epilepsy and the regulation of body heat. To him we owe three new words,
and as such, three new concepts: anaphylaxis, polypnea and zoomotherapy."
Clements Von Pirquet
"Allergy is the term coined by Austrian paediatrician Clemens von Pirquet in 1906 in bringing together the Greek word allos meaning altered and ergia meaning reactivity. Allergy has now come to be known as a term defining altered reactivity to specific substances, which are otherwise harmless to people.
Early reports of Latex Allergy
"Descriptions of apparent allergic reactions to natural rubber appeared in the medical literature in 1927, and irritant and delayed-contact reactions were reported in 1933. Although irritant and delayed-contact reactions to rubber products were increasingly recognized, immediate-type allergic reactions were not reported again until 1979. However, after 1980, increasing numbers of contact urticarial reactions to latex were reported, and investigations suggested that many of these reactions were IgE-mediated. "
History Wheat & Celiac
"In 1819, Dr. John Bostock first accurately described hay fever as a disease that affected the upper respiratory tract. Fifty years later, Charles Blakely performed the first skin test by applying pollen through a small break in the skin."
"In 1913, he was awarded the Nobel Prize for his researches on anaphylaxis. He invented this word to designate the sensitivity developed by an organism after it had been given a parenteral injection of a colloid or protein substance or a toxin (1902). Later he demonstrated the facts of passive anaphylaxis and anaphylaxis in vitro. The applications of anaphylaxis to medicine are extremely numerous. "